Office-Medical School 8-213
Biography David M. Krzywanski received his Bachelor’s Degree in Biology from Millersville University in 1999 and did his graduate training in the laboratories of Drs. Henry J. Forman and Edward Postlethwait in the Department of Environmental Health Sciences at the University of Alabama at Birmingham, Birmingham, AL. He received his Ph.D. from the University of Alabama at Birmingham in 2006 and subsequently trained as a Postdoctoral Fellow at the University of Alabama at Birmingham in the laboratory of Scott Ballinger, Ph.D. to study mitochondrial biology in cardiovascular disease. The early part of his career was spent characterizing unique roles that reactive species play in cellular pathophysiology and the development of disease. He was able to demonstrate that inhaled environmental reactive species could have a negative impact on the development of atherogenesis and that increased oxidative stress could contribute to a fibrogenic phenotype. In 2012 he joined the faculty in the Department of Cellular Biology and Anatomy at LSU Health Sciences Center in Shreveport. There are two current research arms in the Krzywanski laboratory. The first is focused on investigating how the mitochondrial protein nicotinamide nucleotide transhydrogenase (NNT) impacts mitochondrial function and the progression of cardiovascular diseases through the regulation of mitochondrial redox balance. The second is investigating how ethnic differences in mitochondrial function may contribute to the increased prevalence of hypertension in African American populations compared to other ethnicities.
Dr. Krzywanski is active in the scientific community reviewing grants for the American Heart Association and manuscripts for numerous journals including Redox Biology and The Journal of the American Society for Hypertension among others. The Krzywanski laboratory has been funded by the Louisiana Board of Regents and the Louisiana Clinical and Translational Studies Program since 2013.
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